The AIM-HIGH Study was an investigator-initiated trial that was approved and sponsored by the National Heart, Lung, and Blood Institute (NHLBI). The design and organization of the trial and the baseline data have been described previously. Abbott Laboratories provided additional support from an unrestricted research grant. The extended-release niacin (Niaspan), the matching placebo
The original composite primary end point consisted of death from coronary heart disease, nonfatal myocardial infarction, ischemic stroke, or high-risk acute coronary syndrome.14 Because the rate of the primary end point was lower than projected, the protocol was amended to change the end point of “high-risk acute coronary syndrome” to include hospitalization for an acute coronary syndrome and symptom-driven coronary
More than 18 million North Americans have coronary heart disease, and despite profound advances in both pharmacologic and interventional management, both morbidity and mortality remain appreciable.1,2 Elevated low-density lipoprotein (LDL) cholesterol levels are an established predictor of the risk of coronary heart disease.